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Tamoxifen s pharmacological profile indicates that it is a prodrug, and its anticancer activity occurs via its active metabolite, 4 hydroxy tamoxifen 8 and its desmethyl analogue endoxifen 10, which are generated by the action of hepatic CYP 2D6 and CYP3A4 3A5 isozymes on tamoxifen after hydroxylation followed by N demethylation 44e45 stromectol info |
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发表于 2022-10-28 10:27:49
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